Thereafter, a large randomized, controlled trial carried out in the Gambian communities demonstrated the powerful effect of periconceptional maternal nutrition on DNA methylation in offspring blood and hair and was predicted msternal periconceptional maternal plasma concentrations of key micronutrients, such as homocysteine, folate, and B vitamins. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. To substantiate existing evidence of clinical studies, more large-scale clinical trials are necessary.įindings from the unadjusted models were similar to the findings from the adjusted models and therefore are not presented separately.
#The offspring torrent plus#
The current article gives an overview of pathophysiological changes associated with maternal obesity and their consequences on placental structure and function.įor participants without information on pre-pregnancy BMI 4.Įur J Clin Nutr SHBG could represent an integrating biomarker for an adverse cardio-metabolic profile in pregnant women with pregestational plus gestational obesity. The current review will discuss the evidence for the role of maternal obesity in the developmental programming of chronic metabolic disease in offspring, particularly focussing on the role of fetal programming in the development of CKD.
Though often associated with fetal overgrowth, maternal obesity can also conversely be associated with increased risk of premature birth and low birth weight, with implications for renal development and CKD risk. Values represent the absolute risks of any adverse maternal and infant outcome left panel and the percentages of participants right panel for each combination of body mass index and gestational weight gain.
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